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STEVEN L. KAGEN, M.D.

CITIZEN: U.S.A.

EDUCATION:
College:
University of Wisconsin
1972 B.S. Honors
Molecular Biology
Medical School: University of Wisconsin
School of Medicine
Madison, WI
1972-1976 M.D.

Internship & Residency:
Internal Medicine
Northwestern University
School of Medicine
Chicago, IL
1976-1979

Fellowship:
Allergy/Immunology
Medical College of Wisconsin
Milwaukee, WI
1979-1981

BOARD CERTIFICATION:

  • American Board of Internal Medicine, September 1979
  • American Board of Allergy & Immunology, October 1981
  • American Board of Allergy & Immunology - Diagnostic Laboratory Immunology, October 1988

UNIVERSITY AFFILIATIONS:

Assistant Clinical Professor
Division of Allergy & Clinical Immunology
Dept. of Medicine
Medical College of Wisconsin
Milwaukee, WI

HOSPITAL STAFF APPOINTMENTS:

Active, Department of Medicine,
St. Elizabeth Hospital, Appleton, WI

Active Staff, Department of Medicine,
Mercy Medical Center, Oshkosh, WI

Active Staff, Department of Medicine,
Appleton Medical Center, Appleton, WI

Affiliate Staff, Department of Medicine,
Bellin Hospital, Green Bay, WI

Courtesy, Department of Medicine,
St. Vincent Hospital, Green Bay, WI

Courtesy, Department of Medicine,
St. Mary's Hospital, Green Bay, WI

Consulting Staff, HCA Medical Center,
Port St. Lucie, FL

PROFESSIONAL SOCIETIES:

  • American Academy of Allergy, Asthma & Immunology
  • American College of Allergy, Asthma & Immunology
  • Wisconsin Allergy Society
  • State Medical Society of Wisconsin
  • American Medical Association
  • American Meteorological Society, Associate Member

COMMITTEE MEMBERSHIP:

  • American Academy of Allergy, Asthma & Immunology:
  • Insect Allergy Committee
  • Occupational Lung Disease Committee
  • Latex Allergy Committee
  • Fire Ant Allergy Committee

BOARD OF DIRECTOR:

  • Charlie Davidson Leukemia Fund
  • Massachusetts General Hospital, Boston, MA

SPECIAL PROJECTS:

Author and Project Director
"Helpful Hints" on Kleenex Packages.
over 2 billion consumer encounters.

Author, Project Director
"Allergy Relief Guide"
A 34 page consumer education booklet.
Distribution over 50,000.

NPN®, National Pollen Network
Owner, 3-D graphics visualization of pollen and mold counts.
Distribution to television and print media.
A national pollen and mold data bank service.

AllerLab®, Owner and Director
A national diagnostic immunology reference
laboratory.

Aller-Rhythm® allergy test
Owner, registered trademark.
Color-graphic patient education information.

DUST MITE PATENT:

U.S. patent awarded to Steven L. Kagen, M.D. and R. Muthiah, PhD, for the discovery and sequencing of the major allergen of the dust mite (L. destructor).
U.S. Patent No. 5,236,834, Allergenic Molecules from Lepidoglyphus Destructor.

Worldwide patent issued August, 1993.

FOX CITIES CHILDREN'S MUSEUM:

Creator/developer of the "Allergy ArcadeTM ", an interactive educational exhibit designed to teach children and their parents about the world of allergy. A permanent exhibit in Appleton, Wisconsin, with traveling exhibits as well.

CNN ALLERGY CONSULTANT:

Providing daily national allergy related information to CNN in graphic form 1995 to present in collaboration with Board Certified Allergy Specialists throughout the United States as part of NPN, National Pollen Network.

THE WEATHER CHANNEL:

Dr. Steve Kagen (NPN) provided daily national pollen and mold graphics to The Weather Channel through 1994, educating the United States public about the importance of aeroallergens as causes of asthma and hay fever.

ALLERNET.COM

Author/creator of AllerNet.comTM a worldwide web site designed to provide the general public with useful allergy/immunology and asthma information along with referral services to certified allergy specialists throughout the United States.
(http://www.allernet.com)

DISTINCTIONS:

Steve Kagen, M.D., is the only Wisconsin allergist who is Board Certified in Diagnostic Laboratory Immunology.

HONORS:

Voted by physician colleagues as one of the "Best Doctors in America" 1996-1997.

PUBLICATIONS:

Interleukins

1. Soluble mediators of cellular immunity: partial characterization of blastogenic factor. Honors Thesis, University of Wisconsin, 1972.

Marijuana Asthma

 2. Kagen SL, Fink JN, Sohnle P and Kurup VP. Marijuana smoking as a source of Aspergillus exposure. In Proceedings of the 37th Annual Meeting of the American Academy of Allergy, March 1981, San Francisco, CA, p. 63.

3. Kagen SL, Sohnle P, Kurup VP and Fink JN. Aspergillus: An inhalable contaminant of marijuana. New England Journal of Medicine. 1981;304:483-84.

4. Kagen SL, Fink JN, Schlueter DP, et al. Anti- Induced Asthma static agent as a cause of small airway disease. In Proceedings of the 37th Annual Meeting of the American Academy of Allergy, March, 1981, San Francisco, CA, P. 30.

Hypersensitivity

5. Kagen SL, Fink JN, Schlueter DP, Kurup VP, Pneumonitis and Fruchtman R. Streptomyces albus: A new cause of hypersensitivity pneumonitis. J Allergy Clin Immunol. 1981;68:295-99.

Allergic Aspergillosis

6. Kagen SL, Cohen SH and Kurup VP. Ketoconazole therapy of allergic bronchopulmonary aspergillosis. Presented at the International Congress of Allergology and Clinical Immunology. London, England, 1982.

Diagnostic Allergy

7. Cohen SH and Kagen SL. Cimetidine and Skin Testing allergy skin testing. Annals of Internal Medicine. 1981;96:787.

8. Kagen SL, Schlueter DP, Cohen SH. Induction of small airways disease by a fabric softener. Manuscript submitted for publication.

9. Kagen SL, Kurup VP, Sohnle PG, and Fink JN. Marijuana smoking and fungal sensitization, J Allergy Clin Immunol. 1983;71:389-93.

Smoking & Asthma

10. Kurup VP, Resnick A, Kagen SL, Cohen SH and Fink JN. Allergic fungi and actinomycetes in smoking materials and their health implications. Mycopathologia. 1983;82:61-4.

AIDS

11, Nunnink JC, Wiedmeyer J, Hank J, Kagen SL and Sondel PS. Characterization of a possible suppressive factor in AIDS. UCLA AIDS Symposium, Salt Lake City, Utah, 1983.

Insect Allergy

12. Kagen SL, Yunginger J, and Johnson R. Lake fly allergy: Incidence of chironomid sensitivity in an atopic population. In Proceedings of the 40th Annual Meeting of the American Academy of Allergy & Immunology, March, 1984, Chicago, IL.

13. Kagen SL. Inhalant insect allergy. In Monograph on Insect Allergy, 1986 pp 93-102. (Levine MI and Lockey RF eds). D. Lambert Associates, Pittsburgh, PA.

Occupational Insect

14. Kagen SL, Yunginger J and Wynn SR. Allergy & Asthma Occupational respiratory allergy due to caddisfly aeroallergens. J Allergy Clin Immunol. 1986;77:169

Insect Allergen

15. Kagen SL, Yunginger J, Wynn SR and Swanson Immunotherapy MC. Midge-specific IgE and IgG responses during lake fly desensitization: An open trial. J Allergy Clin Immunol. 1986;77:140.

16. Kagen SL. Inhalant allergy to arthropods: Insects, arachnids, and crustaceans. Clin Rev Allergy. 1990;8:99-125.

Caddisfly Allergens

17. Kagen SL, Koshte V, and Aalberse R. Cross-reactivity of caddisfly-specific IgE antibodies with arthropoda and mollusca. Allergy Proceedings. 1988;9:289.

18. Koshte VL, Kagen SL and Aalberse R. Cross-reactivity of IgE antibodies to caddisfly with arthropoda and mollusca. J Allergy Clin Immunol. 84:174-83, 1989.

Cloning of Insect

19. Kagen SL and Siebert P. Cloning of insect Allergens aeroallergens: midge hemoglobins. Allergy Proceedings. 1988;9:281.

Rapid Desensitization

20. Bernstein D, Mittman RJ, Kagen SL, Korbe BS to Venom and Bernstein IL. Safety and efficacy of rapid venom immunotherapy (RVIT) for treatment of Hymenoptera-sensitive patients. J Allergy Clin Immunol. 1989;83:227.

Fire Ant Allergy

21. Kagen SL and Muthiah R. Fire ant anaphylaxis: Allergen characterization and partial amino acid sequence of Sol i II and Sol i III. Ann Allergy. 1990;64:75.

Occupational Lung Disease

22. Bush R and Kagen SL. Guidelines for the preparation and characterization of high molecular weight allergens used for the diagnosis of occupational lung disease. J Allergy Clin Immunol. 1989;84:814-19.

Rapid Desensitization

23. Bernstein D, Mittman RJ, Kagen SL, Korbee L, to Venom Enrione M and Berstein IL. Clinical and immunologic studies of rapid venom immunotherapy in Hymenoptera-sensitive patients. J Allergy Clin Immunol. 1989;84:951-59.

Food Allergens: Buckwheat

24. Muthiah R and Kagen SL. Food Allergens: Characterization of major buckwheat carbohydrate dependent allergens. J Allergy Clin Immunol. 1990;85:151.

Insect Allergens:

25. Kagen SL and Muthiah R. Insect allergens: Hemoglobins Characterization and partial sequencing of a caddisfly hemoglobin. J Allergy Clin Immunol. 1990;85:152.

Allergy Vaccine Stability

26. Muthiah R and Kagen SL. Allergens as enzymes: Degradation of cat and ragweed allergens by house dust mite allergen extract. J Allergy Clin Immunol. 1990;85:151.

27. Kagen SL, Isaacson B and Muthiah R. Polymerized ragweed vaccine: Retention of all epitopes. J Allergy Clin Immunol. 1991;87:188.

Allergy Vaccine Stability

28. Knoll R, Kagen SL and Muthiah R. Allergens as enzymes: Failure of HSA to protect degradation of grass allergens by mold extracts. J Allergy Clin Immunol. 1991;87:188.

Barn Allergy:

29. Muthiah R, Miller M and Kagen SL. Barn Storage Mite Allergens allergy: Isolation and characterization of the major allergens of storage mites: L. destructor. J Allergy Clin Immunol. 1991;87:326.

Fire Ant Allergy

30. Knoll R, Kagen S and Muthiah R. Non-specific reactivity of fire ant whole body extract in the diagnosis of fire ant allergy. J Allergy Clin Immunol. 1992;89:51.

Immunization Screen

31. Muthiah R, Kagen S, Hildeman D and Knoll R. New Immunization screen reveals under-immunization of patients attending allergy & asthma clinics. J Allergy Clin Immunol. 1992;89:490.

Protective Levels to

32. Kagen S, Muthiah R, Hildeman D, Knoll R and Fire Ant Venom Friedman S. Fire ant anaphylaxis: Initial determination of fire ant-specific IgG anti-toxin levels. J Allergy Clin Immunol. 1992;89:716.

Allergen Immunotherapy

33. Kagen SL. Other indications for administration of allergy immunotherapy: Insects, fire ants and therapeutic agents. Immunology and Allergy Clinics of North America. 1992;12:177-97.

Rapid Venom Immunotherapy

34. Bernstein JA, Kagen SL, Bernstein DI and Bernstein IL. An extended experience indicating that rapid venom immunotherapy (RVIT) is safe for treatment of Hymenoptera (Hym) anaphylaxis. J Allergy Clin Immunol. 1993;91:563.

Polymerized Midge Allergen

35. Knoll R, Kagen SL, Muthiah R and Hildeman. Immunotherapy Polymerized midge allergen immunotherapy (PMAIT): clinical reduction in early and late phase reactivity and prevention of rhinitis and asthma morbidity. J Allergy Clin Immunol. 1994;93:251.

Polymerized Grass Allergen

36. Hildeman D, Muthiah R and Kagen SL. Immunotherapy Successful polymerized grass allergen immunotherapy (PGAIT): failure of in vitro measurements to correlate with clinical outcomes. J Allergy Clin Immunol. 1994;93:251.

Polymerized Ragweed Allergen

37. Hempel D, Muthiah R, Hildeman D and Kagen SL. Immunotherapy Polymerized ragweed allergen immunotherapy (PRAIT): failure of anti-idiotypic antibody (AIA) to predict clinical outcomes. J Allergy Clin Immunol. 1994;93:251.

Helicobacter Pylori

38. Zondlo J, Muthiah R, Knoll R and Kagen SL. Helicobacter pylori (Hp): a new cause of urticaria (U) and exercise-induced anaphylaxis (EIA) - identification of Hp allergens. J Allergy Clin Immunol. 1994;93:220.

Allergen Extract Stability

39. Kagen SL, Muthiah R and Knoll R. Allergens as enzymes: a two year study of aqueous allergen extract stability and the deleterious effect of mixing allergen extracts together. J Allergy Clin Immunol. 1994;93:253.

Frog-induced Anaphylaxis

40. Muthiah R, Kagen SL and Hempel D. Frog-induced anaphylaxis (ANA): isolation and characterization of the major frog allergen, which is cross-reactive with cod parvalbumin. J Allergy Clin Immunol. 1994;93:209.

Rapid Venom Immunotherapy

41. Bernstein JA, Kagen SL, Bernstein DI and Bernstein LB. Rapid venom immunotherapy is safe for routine use in the treatment of patients with Hymenoptera anaphylaxis. Annals of Allergy. 1994;73:423-8.

Flaxseed-Induced Anaphylaxis

42. Muthiah R, Louthain L, Knoll R and Kagen S. Flaxseed-induced anaphylaxis (ANA): another cross-reactive carbohydrate food allergen. J Allergy Clinic Immunol. 1995;95:370.

Helicobacter pylori

43. Kagen S, Zondlo A, Zondlo J and Muthiah R. Helicobacter pylori and allergic disease: characterization of Helicobacter allergens. J Allergy Clin Immunol. 1995;95:255.

Insect Allergy

44. Kagen SL and Chapman M. Allergy to inhalants of arthropods: insects and arachnids. In Monograph on Insect Allergy. 1995;95:370.

Eggplant Anaphylaxis

45. Muthiah R, Zondlo A, Zondlo J and Kagen S. Eggplant anaphylaxis: isolation of the major allergens and demonstration of cross-reactivity with other Solanaceae. Allergy Clin Immunol. 1996;97:334.

Aerobiology

46. Kagen S, Muthiah R, Knoll R, Graphos G and DeStasio B. Aerobiology: Grass pollen forecasting models. Allergy Clin Immunol. 1996;97:217.

Mannose Binding Protein

47. Kagen S, Muthiah R and Slupianek J. Mannose Deficiency binding protein deficiency is more frequent than IgA deficiency. Allergy Clin Immunol. 1997;99:S396.

Allergy to Acacia in Synthroid

48. Muthiah R, Kagen S, Zondlo A and Zondlo J. Hidden allergens in medications: Allergy to acacia in Synthroid tablets. Allergy Clin Immunol. 1997;99:S492.

Latex & Food Anaphylaxis

49. Kagen SL and Muthiah R. Latex and Food induced Anaphylaxis: Oregano, Dill, Sage and Carrot Cross-React with Natural Rubber Latex. Allergy Clin Immunol. 1998;101:858.

Chinchilla Allergy

50. Muthiah R, Yablon B, Reddy, and Kagen S. Chinchilla Allergy: A new Cause of Animal Hypersensitivity. Allergy Clin Immunol. 1999;103:93.

Anaphylaxis to PPD

51. Kagen S and Muthiah R. Anaphylaxis to PPD: Tuberculosis Skin Test Antigen Atopy. Allergy Clin Immunol. 1999;103:149.

Latex Allergy

52. Kagen SL and Muthiah R. Latex, Almond and Tobacco: Cross-Reactive Allergens. Annals of Allergy, Asthma & Immun. Jan 2000. In press.

Latex and Ginger Allergens

53. Muthiah R, Peterson A and Kagen SL. Latex and Ginger Allergy. Annals of Allergy, Asthma & Immun. Jan 2000. In press.

Ladybug Allergy

54. Kagen SL and Muthiah R. Ladybugs: A New Cause of Allergy. Annals of Allergy, Asthma & Immun. Jan 2000. In press.